PT  - JOURNAL ARTICLE
AU  - J. M. ROBSON
AU  - M. Y. ANSARI
TI  - THE FATE OF D.B.E. (αα DI-(p-ETHOXYPHENYL)β-PHENYL BROMO-ETHYLENE) IN THE BODY
DP  - 1943 Dec 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 340--345
VI  - 79
IP  - 4
4099  - http://jpet.aspetjournals.org/content/79/4/340.short
4100  - http://jpet.aspetjournals.org/content/79/4/340.full
SO  - J Pharmacol Exp Ther1943 Dec 01; 79
AB  - D.B.E. was administered to ovariectomized mice by stomach tube. Twenty-four hours later, less than 50% of the dose could be recovered from the body, but after that the elimination became slower and was almost completed in 3 weeks. The highest concentration of the substance was found in the body fat from which it was more slowly eliminated than from the rest of the body. Only 5-10% of the dose given could be recovered from the excreta. Most of this was present in the faeces. In vitro experiments suggest that the liver does not play an important part in the inactivation of the substance. The mode of action of D.B.E. is discussed and it is suggested that it may be suitable for the treatment of conditions in which prolonged oestrogenic action is required.