@article {HARRIS83, author = {PAUL N. HARRIS and ROBERT C. ANDERSON and K. K. CHEN}, title = {THE ACTION OF ISATIDINE, PTEROPHINE, AND SCELERATINE}, volume = {75}, number = {1}, pages = {83--88}, year = {1942}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {1. The acute toxicity of isatidine, sceleratine, and pterophine has been determined in mice by intravenous injection. The last alkaloid is the most, and isatidine the least, toxic{\textemdash}sceleratine being intermediate. 2. Mice receiving lethal doses of the 3 alkaloids die in 1-5 days. Necropsies of these animals reveal liver necrosis associated with sinusoidal congestion and hemorrhage into the cords of necrotic cells. With pterophine, the necrosis is predominantly periportal; but with isatidine and sceleratine, it is chiefly central. 3. Doses far in excess of the median lethal doses of the 3 alkaloids may kill mice within a few minutes. Postmortem examination of 5 such animals following intravenous injection of isatidine shows some hydrops of the liver in 4, and pulmonary edema in 2. 4. Pterophine, when injected intravenously in cats, has a depressor action; it inhibits isolated rabbits{\textquoteright} intestines and contracts isolated guinea pigs{\textquoteright} uteri. Sceleratine and isatidine slightly raise blood pressure in cats following intravenous injection, and stimulate isolated guinea pigs{\textquoteright} uteri.}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/75/1/83}, eprint = {https://jpet.aspetjournals.org/content/75/1/83.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }