RT Journal Article SR Electronic T1 THE ACTION OF MONOCROTALINE AND RETRONECINE JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 78 OP 82 VO 75 IS 1 A1 PAUL N. HARRIS A1 ROBERT C. ANDERSON A1 K. K. CHEN YR 1942 UL http://jpet.aspetjournals.org/content/75/1/78.abstract AB 1. The acute toxicity of monocrotaline and retronecine has been determined in mice. 2. Monocrotaline produces liver necrosis associated with sinusoidal congestion and hemorrhage into necrotic cell cords. Repeated administration of monocrotaline appears to cause hypertrophy of liver cells. 3. Intravenous injection of large doses of retronecine is followed by either rapid death or complete recovery. No hepatic injury has resulted. 4. Monocrotaline inhibits isolated rabbits' intestines, and has a slight depressor action in cats. Retronecine reduces cats' blood pressure in relatively large doses, and stimulates the isolated guinea pig's uterus. In dilute concentration, retronecine inhibits isolated rabbits' intestines, but in stronger solutions, it augments them.