PT  - JOURNAL ARTICLE
AU  - PAUL N. HARRIS
AU  - ROBERT C. ANDERSON
AU  - K. K. CHEN
TI  - THE ACTION OF SENECIONINE, INTEGERRIMINE, JACOBINE, LONGILOBINE, AND SPARTIOIDINE, ESPECIALLY ON THE LIVER
DP  - 1942 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 69--77
VI  - 75
IP  - 1
4099  - http://jpet.aspetjournals.org/content/75/1/69.short
4100  - http://jpet.aspetjournals.org/content/75/1/69.full
SO  - J Pharmacol Exp Ther1942 May 01; 75
AB  - 1. The median lethal doses of senecionine, integerrimine, jacobine, longilobine, and spartioidine, have been determined in mice by intravenous injection. Death occurs in 24-96 hours following medication. 2. Necropsies have been performed on all animals, dead or surviving for a week. Necrosis of the liver, chiefly central, associated with sinusoidal congestion and hemorrhage into cell cords is uniformly observed. 3. Repeated administration of small sublethal doses of the 5 alkaloids, intravenously, subcutaneously, or orally, is followed by hypertrophy of the liver cells and their nuclei. In no instance is cirrhosis of the liver observed. 4. All the 5 alkaloids lower arterial blood pressure of etherized cats, and inhibit the peristaltic movements of isolated rabbits' intestines. Integerrimine, longilobine, and jacobine cause contractions of isolated guinea pigs' uteri.