%0 Journal Article %A PAUL N. HARRIS %A ROBERT C. ANDERSON %A K. K. CHEN %T THE ACTION OF SENECIONINE, INTEGERRIMINE, JACOBINE, LONGILOBINE, AND SPARTIOIDINE, ESPECIALLY ON THE LIVER %D 1942 %J Journal of Pharmacology and Experimental Therapeutics %P 69-77 %V 75 %N 1 %X 1. The median lethal doses of senecionine, integerrimine, jacobine, longilobine, and spartioidine, have been determined in mice by intravenous injection. Death occurs in 24-96 hours following medication. 2. Necropsies have been performed on all animals, dead or surviving for a week. Necrosis of the liver, chiefly central, associated with sinusoidal congestion and hemorrhage into cell cords is uniformly observed. 3. Repeated administration of small sublethal doses of the 5 alkaloids, intravenously, subcutaneously, or orally, is followed by hypertrophy of the liver cells and their nuclei. In no instance is cirrhosis of the liver observed. 4. All the 5 alkaloids lower arterial blood pressure of etherized cats, and inhibit the peristaltic movements of isolated rabbits' intestines. Integerrimine, longilobine, and jacobine cause contractions of isolated guinea pigs' uteri. %U https://jpet.aspetjournals.org/content/jpet/75/1/69.full.pdf