RT Journal Article
SR Electronic
T1 INFLUENCE OF TEMPERATURE ON THE STIMULATION OF OXYGEN CONSUMPTION OF ISOLATED BRAIN AND KIDNEY BY 2-4 DINITROPHENOL
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 58
OP 63
VO 75
IS 1
A1 FREDERICK A. FUHRMAN
A1 JOHN FIELD, 2D
YR 1942
UL http://jpet.aspetjournals.org/content/75/1/58.abstract
AB The intensity of the acceleration of oxygen consumption of excised rat cerebral cortex and kidney cortex by a given concentration of DNP (3.35 x 10–5 M) varies with temperature. The maximum percentage increase in respiration occurred at 32°C. in cerebral cortex and at 22°C. in kidney cortex. These observations support the hypothesis of Hall (4) that abolition of the cold defense reactions in hypothermic cats by DNP is consequent upon a relative increase in the metabolism of the temperature regulating centers with accompanying decrease in the sensitivity of these centers to the effects of cold stimuli. Values of the temperature coefficient, Q10, for the respiration of excised cerebral and kidney cortex were calculated for small intervals over the range 10° to 42°C. For both tissues there was a progressive decrease in Q10 from 10° to 30°C., followed by a definite rise in the range 30° to 35°C., with diminution on further rise in temperature.