PT - JOURNAL ARTICLE AU - GERALDINE J. FUHRMAN AU - FRANK W. WEYMOUTH AU - JOHN FIELD, 2D TI - THE EFFECT OF ENVIRONMENTAL TEMPERATURE ON THE TOXICITY OF 2,4-DINITROPHENOL IN MICE DP - 1943 Oct 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 176--178 VI - 79 IP - 2 4099 - http://jpet.aspetjournals.org/content/79/2/176.short 4100 - http://jpet.aspetjournals.org/content/79/2/176.full SO - J Pharmacol Exp Ther1943 Oct 01; 79 AB - 1. It is shown that the toxicity of 2,4-dinitrophenol in the adult albino mouse is lowered by decrease and raised by increase of environmental temperature between 6° and 40°C. 2. Calculated values of the LD50, for DNP in mgm. per kgm. were 35.7 and 30.9 at 6° and 25° respectively. The difference between these values is significant 3. The LD50 at 40°C. was not determined. However, it is shown that it lies below 8.22 mgm. DNP per kgm. and is significantly lower than the 25°C. value.