RT Journal Article SR Electronic T1 THE BLOOD FLOW IN A PATIENT WITH DOUBLE AORTIC AND DOUBLE MITRAL DISEASE JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 441 OP 447 VO 7 IS 4 A1 L. H. NEWBURGH A1 J. H. MEANS YR 1915 UL http://jpet.aspetjournals.org/content/7/4/441.abstract AB Determinations of the blood flow during rest and in response to increasing amounts of muscular work in a patient with valvular heart disease are reported. No essential differences between the cardiac and normal subject were found. In both the normal and the cardiac subject the oxygen absorption and the blood flow showed a progressive rise with increasing amounts of work. This rise in blood flow was met at first chiefly by an increase in systolic output until a maximum was reached; after that by an increase in pulse rate.