%0 Journal Article %A K. K. CHEN %A ROBERT C. ANDERSON %A FRANK A. STELDT %A C. A. MILLS %T ENVIRONMENTAL TEMPERATURE AND DRUG ACTION IN MICE %D 1943 %J Journal of Pharmacology and Experimental Therapeutics %P 127-132 %V 79 %N 2 %X 1. Of 11 drugs studied in mice at various temperatures, diamino-diphenyl sulfone given by mouth is shown to be approximately 10 times as toxic at 40°C. as at 25°C. 2. Insulin injected by vein is more than 80 times as potent at 40°C. as at 20°C. The onset of convulsions occurs sooner at high temperatures than at low ones. 3. Harmine hydrochloride administered intravenously is also increasingly toxic, although to a less degree, with the rise of temperature. It is about twice as toxic at 40°C. as at 20°C. 4. There is a suggestion that the toxicity of sulfapyridine sodium, sulfathiazole sodium, strychnine sulfate, picrotoxin, tutin, aconitine hydrobromide, and scopolamine hydrobromide, increases with the elevation of temperature— particularly at 40°C. as compared with lower temperatures. The lethal dose of sulfanilamide is least influenced by temperature. 5. Mice appear more susceptible at 40°C. to picrotoxin and tutin in developing convulsions than at 20-25°C. The speed of action is also accelerated at higher temperature levels. %U https://jpet.aspetjournals.org/content/jpet/79/2/127.full.pdf