PT  - JOURNAL ARTICLE
AU  - O. KRAYER
AU  - R. MENDEZ
AU  - E. MOISSET DE ESPANÉS
AU  - R. P. LINSTEAD
TI  - PHARMACOLOGY AND CHEMISTRY OF SUBSTANCES WITH CARDIAC ACTIVITY I. EFFECT OF UNSATURATED LACTONES ON THE ISOLATED FROG HEART
DP  - 1942 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 372--380
VI  - 74
IP  - 4
4099  - http://jpet.aspetjournals.org/content/74/4/372.short
4100  - http://jpet.aspetjournals.org/content/74/4/372.full
SO  - J Pharmacol Exp Ther1942 Apr 01; 74
AB  - The action on the isolated frog heart has been studied of four unsaturated lactones, namely, βγ-angelicalactone, αβ-angelicalactone, crotonolactone γ-acetic acid, and methyl ester of crotonolactone γ-acetic acid. They cause an increase in the amplitude of contraction followed by a period of diminished relaxation of the ventricle which terminates in systolic standstill. The angelicalactones improve the activity of the heart made hypodynamic by perfusion with calcium-poor salt solution. A quantitative comparison of the systolic action showed that the βγ-angelicalactone is considerably more potent than the three αβ-unsaturated lactones.