PT  - JOURNAL ARTICLE
AU  - M. KURODA
TI  - ON THE ACTION OF COCAINE
DP  - 1915 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 423--439
VI  - 7
IP  - 4
4099  - http://jpet.aspetjournals.org/content/7/4/423.short
4100  - http://jpet.aspetjournals.org/content/7/4/423.full
SO  - J Pharmacol Exp Ther1915 Nov 01; 7
AB  - 1. The results of these experiments may be summarised in the following table. [See table in the PDF file] 2. Cocaine therefore first increases the activity of unstriated muscle and then depresses it, whatever be the nature of the sympathetic control. In some instances the phase of increased activity was not observed. 3. It is argued that the dilation of the pupil under cocaine arises from direct action on the muscle of the iris and not from stimulation of the terminations of the sympathetic in the iris. 4. The action of cocaine in first stimulating and then paralysing muscle fibre (including that of the iris) is analogous to its effects on other forms of living matter, including that on sensory organs when directly applied to them.