RT Journal Article
SR Electronic
T1 THE MECHANISM OF MORPHINE MIOSIS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 239
OP 246
VO 74
IS 3
A1 F. D. McCREA
A1 G. S. EADIE
A1 J. E. MORGAN
YR 1942
UL http://jpet.aspetjournals.org/content/74/3/239.abstract
AB 1. Morphine miosis in the dog is to a large extent dependent on the integrity of the optic nerve. 2. The degree of miosis in both dog and man depends very largely, but not altogether, on the amount of light falling on the eye, so that the effect of morphine appears to be mainly an exaggeration of the light reflex. 3. These effects of morphine are potentiated by doses of prostigmine which are in themselves ineffective. 4. The rate of recovery of the pupil from a brief exposure to a bright light is greatly delayed by morphine but does not appear to be further delayed by prostigmine. 5. The significance of these findings is discussed.