RT Journal Article SR Electronic T1 THE ACTION OF RIDDELLINE JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 372 OP 374 VO 78 IS 4 A1 PAUL N. HARRIS A1 ROBERT C. ANDERSON A1 K. K. CHEN YR 1943 UL http://jpet.aspetjournals.org/content/78/4/372.abstract AB 1. The acute toxicity of riddelline has been determined in mice by intravenous injection. 2. Like other Senecio alkaloids so far studied, riddelline produces in mice central necrosis of the liver, ascites or hydrothorax, and pulmonary edema. There is also evidence of necrosis of cortical lymphocytes in the thymus. 3. Riddelline inhibits the isolated rabbit's small intestine and stimulates the isolated guinea pig's uterus. It causes a fall of blood pressure when injected by vein in pithed or barbitalized cats.