TY - JOUR T1 - THE FATE OF SULFONAMIDES AND <em>p</em>-AMINOBENZOIC ACID IN COLD-BLOODED ANIMALS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 366 LP - 371 VL - 78 IS - 4 AU - ROBERT B. FAILEY, JR. AU - ROBERT C. ANDERSON AU - FRANCIS G. HENDERSON AU - K. K. CHEN Y1 - 1943/08/01 UR - http://jpet.aspetjournals.org/content/78/4/366.abstract N2 - 1. Sulfanilamide, sulfapyridine, sulfathiazole, sulfadiazine, or p-aminobenzoic acid, in the form of the sodium salt, when injected into the ventral lymph sac of the spadefoot toad (Scaphiopus holbrookii holbrookii), or the nebulous toad (Bufo valliceps), is partly conjugated as shown in blood and urine. The degree of conjugation as observed in blood is apparently not as great as in the rabbit. In the nebulous toad's blood, the conjugated form of sulfadiazine is unmeasurable. 2. Similarly, conjugation takes place in the tree frog (Hyla cinerea cinerea) with sulfanilamide, sulfapyridine, sulfathiazole, and sulfadiazine. 3. Confirmatory of Marshall's work, sulfanilamide, sulfapyridine, and sulfathiazole are found to be unconjugated in the Leopard frog (Rana pipiens) and the "Jumbo" bullfrog (Rana catesbeiana). Also, sulfadiazine and p-aminobenzoic acid are not conjugated in the former animal. 4. No conjugation takes place in the turtle (Pseudemys elegans) with sulfanilamide, sulfapyridine, sulfadiazine, or p-aminobenzoic acid. There is, however, a slight conjugation with sulfathiazole. ER -