TY - JOUR T1 - THE URICOSURIC EFFECTS OF CERTAIN POLYHYDRIC ALCOHOLS AND SACCHARIDES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 106 LP - 113 VL - 74 IS - 2 AU - G. P. GRABFIELD AU - D. SWANSON Y1 - 1942/02/01 UR - http://jpet.aspetjournals.org/content/74/2/106.abstract N2 - 1. The effects of intravenous injections of hypertonic solutions of certain polyhydric alcohols and saccharides have been studied in dogs with exteriorized ureters without anesthesia. 2. These drugs produce not only a diuresis but also a marked increase in uric acid and allantoin excretion. 3. All substances causing the increase in purine excretion have the CH2OH grouping at both ends of the chain. 4. This is not accomplished through a nervous mechanism. 5. It is unlikely that the hypertonicity of the solution per se is the cause of uric acid mobilization, since some hypertonic solutions do not produce this result. ER -