RT Journal Article
SR Electronic
T1 AN IN VITRO STUDY ON THE SYNERGISTIC ACTION OF SULFAMIDO COMPOUNDS AND AZOCHLORAMID UPON VARIOUS PATHOGENIC MICROORGANISMS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 52
OP 60
VO 74
IS 1
A1 ERWIN NETER
YR 1942
UL http://jpet.aspetjournals.org/content/74/1/52.abstract
AB An in vitro study on the combined antibacterial activity of sulfamido compounds and azochloramid revealed the following: 1. Azochloramid used in combination with suffanilamide, suffathiazol, and and sulfadiazine may exert greater bacteriostatic activity toward Group A hemolytic streptococcus than does either compound alone in like or somewhat higher concentrations. 2. A slight increase in bacteriostatic activity toward Group D hemolytic streptococcus was obtained when azochloramid was used in conjunction with sulfanilamide. 3. The combined use of azochloramid and sulfanilamide, sulfapyridine, sulfathiazol or sulfadiazine resulted in greater inhibition of growth of penumococcus type I than did that of either drug alone in like or somewhat higher concentrations. 4. The combined use of sulfathiazol or sulfadiazine and azochloramid retarded the growth of staphylococcus aureus hemolyticus to a greater extent than did either drug in like or higher concentrations.