RT Journal Article
SR Electronic
T1 STUDIES ON THE DETOXICATION OF ORGANIC ARSENICAL COMPOUNDS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 203
OP 208
VO 78
IS 2
A1 J. H. SANDGROUND
A1 CHARLES R. HAMILTON
YR 1943
UL http://jpet.aspetjournals.org/content/78/2/203.abstract
AB 1. By the administration of sufficient p-aminobenzoate, essentially all rats may be protected against a "Universal Lethal Dose" (LD100) of such phenyl arsonates as carbarsone and arsanilic acid (= `Atoxyl'). Beyond this arsenical dose level, there is a gradual decrease in the group survival rate. 2. A single injection of p-aminobenzoate is capable of conferring the protection. 3. Against the LD90 quantity of these pentavalent arsenicals, protection is afforded by a relatively smaller dose of p-aminobenzoate; 15 mgm./kg. was found sufficient to protect 50% of individual rats and to prolong the survival time of a group of rats receiving 400 mgm./kg. of arsanilic acid.