RT Journal Article
SR Electronic
T1 THE EFFECTS OF MECHOLYL, POTASSIUM CHLORIDE AND PROSTIGMINE ON NEUROMUSCULAR ATROPHY AND REGENERATION
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 463
OP 467
VO 73
IS 4
A1 H. M. HINES
A1 J. D. THOMSON
A1 B. LAZERE
YR 1941
UL http://jpet.aspetjournals.org/content/73/4/463.abstract
AB The daily oral administration of 4.8 mgm. of mecholyl, 47 mgm. of potassium chloride and 0.72 mgm. of prostigmine to adult albino rats with lesions in their tibial nerves neither delayed muscular atrophy nor hastened neuromuscular regeneration. The criteria employed in the studies include quantitative determinations of the weight changes, creatine concentration and strength of the gastrocnemius muscle at various times after denervation. A discussion is included of the reports of other investigators concerning the favorable influence of these drugs on muscular atrophy and recovery from paralysis.