RT Journal Article
SR Electronic
T1 THE EFFECT OF COCAINE, ERGOTAMINE AND YOHIMBINE ON THE ACTIVITY OF PHENOL SULFUR ESTERASE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 123
OP 126
VO 77
IS 2
A1 CLARA TORDA
YR 1943
UL http://jpet.aspetjournals.org/content/77/2/123.abstract
AB 1. The effect of cocaine, ergotamine and yohimbine on the activity of the phenol sulfur esterase has been investigated. 2. Cocaine inhibits the activity of this enzyme while ergotamine and yohimbine increase it. 3. This study suggests that the inactivation of the phenol sulfur esterase is one mechanism by which cocaine potentiates the action of epinephrine, and a potentiation of the activity of phenol sulfur esterase is one mechanism by which ergotamine or yohimbine depress the action of epinephrine.