PT  - JOURNAL ARTICLE
AU  - SANFORD M. ROSENTHAL
TI  - THE TRYPANOCIDAL ACTION OF <em>3</em>-AMINO-<em>4</em>-HYDROXYPHENYL ARISENIOUS OXIDE ("MAPHARSEN") ADMINISTERED ORALLY WITH GLUTATHIONE
DP  - 1942 Dec 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 358--362
VI  - 76
IP  - 4
4099  - http://jpet.aspetjournals.org/content/76/4/358.short
4100  - http://jpet.aspetjournals.org/content/76/4/358.full
SO  - J Pharmacol Exp Ther1942 Dec 01; 76
AB  - 3-Amino-4-hydroxyphenyl arsenious oxide administered by mouth possesses curative action against Trypanosome equiperdum infections in mice. The addition of 2 moles of glutathione decreased toxicity without affecting therapeutic activity, giving a therapeutic ratio that compares favorably with intravenous administration. Preliminary experiments indicate some therapeutic action in rabbit syphilis following oral therapy.