TY - JOUR T1 - METABOLISM, TOXICITY AND MANNER OF ACTION OF GOLD COMPOUNDS USED IN THE TREATMENT OF ARTHRITIS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 355 LP - 357 VL - 76 IS - 4 AU - WALTER D. BLOCK AU - OLIVER H. BUCHANAN AU - R. H. FREYBERG Y1 - 1942/12/01 UR - http://jpet.aspetjournals.org/content/76/4/355.abstract N2 - (1) Following the intramuscular injection of oily suspensions of gold calcium thiomalate and gold thioglucose in the white rat the rate of absorption of gold is somewhat faster in the case of the latter compounds. (2) Gold was found in larger amounts in the kidneys and liver than in other tissues studied. (3) Excretion occurs through both the kidneys and gastro-intestinal tract. The chief route of excretion of the soluble gold thioglucose is the kidneys while gold is excreted primarily in the feces following administration of the insoluble gold calcium thiomalate. ER -