TY - JOUR T1 - THE EXPERIMENTAL PRODUCTION OF PRIMARY OPTIC ATROPHY IN MONKEYS BY ADMINISTRATION OF ORGANIC ARSENICAL COMPOUNDS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 202 LP - 206 VL - 76 IS - 2 AU - B. J. LONGLEY AU - N. M. CLAUSEN AU - A. L. TATUM Y1 - 1942/10/01 UR - http://jpet.aspetjournals.org/content/76/2/202.abstract N2 - 1. Blindness has been produced in monkeys by the administration of the following compounds: atoxyl, tryparsamide, stovarsol, 3-amino-4-beta-hydroxy-ethoxy-phenylarsonic acid (No. 190), and 4-β-(β'-hydroxy)ethoxy-ethoxy-phenylarsonic acid (No. 266), the last containing no nitrogen in the molecule. 2. The work herein reported would appear to provide an experimental basis for detecting the blinding potentialities of arsenical compounds for man. 3. Means now become available for a study of prophylactic procedures designed to reduce or eliminate optic atrophy as a sequence of chemotherapy of neurosyphilis. ER -