RT Journal Article
SR Electronic
T1 STUDIES ON THE TOLERANCE FORMATION TO GOLD SODIUM THIOSULPHATE IN RATS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 17
OP 20
VO 76
IS 1
A1 RUTH CORTELL
A1 R. KOHN RICHARDS
YR 1942
UL http://jpet.aspetjournals.org/content/76/1/17.abstract
AB Tolerance formation to usually fatal amounts of gold sodium thiosulphate in rats can be developed by the repeated intramuscular injection of doses ranging from 20 to 35 mgm./kgm. The mechanism of the tolerance formation is related to the development of a resistance of the epithelial cells of the tubules of the kidney to the damaging effects of the gold salt.