TY - JOUR T1 - A STUDY OF THE COMPARATIVE TOXIC EFFECTS OF MORPHINE ON THE FETAL, NEWBORN AND ADULT RATS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 363 LP - 366 VL - 75 IS - 3 AU - ANNETTE CHESLER AU - GILES C. LABELLE AU - HAROLD E. HIMWICH Y1 - 1942/07/01 UR - http://jpet.aspetjournals.org/content/75/3/363.abstract N2 - Lethal doses of morphine sulphate were administered to 116 adult rats, 300 newborn rats, and 11 pregnant rats at full term. The newborn rats were more resistant to acute respiratory failure than the adult rats, but the fetuses were about equal in susceptibility to their mothers. Probable causes for the characteristic susceptibility of fetal, newborn, and adult rats to lethal doses of morphine are discussed. ER -