RT Journal Article
SR Electronic
T1 STUDIES ON SULFONAMIDE-RESISTANT ORGANISMS: II. COMPARATIVE DEVELOPMENT OF RESISTANCE TO DIFFERENT SULFONAMIDES BY PNEUMOCOCCI
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 356
OP 362
VO 75
IS 3
A1 CLARA L. SESLER
A1 L. H. SCHMIDT
YR 1942
UL http://jpet.aspetjournals.org/content/75/3/356.abstract
AB A study of some of the factors involved in the development of sulfonamide-resistant pneumococci showed the following: (1) Strains of pneumococcus differed in the ease with which they developed resistance to a given sulfonamide. (2) There was a difference in the rates at which a single strain of pneumococcus developed resistance to the various sulfonamides. In all instances, resistance was developed most rapidly to the least effective drug and most slowly to the most effective drug. (3) When a strain of pneumococcus had acquired resistance to one sulfonamide, it was also resistant to all the other sulfonamides tested.