RT Journal Article SR Electronic T1 FURTHER OBSERVATIONS ON THE ACTION OF DRUGS ON THE CALIBER OF CORONARY VESSELS PAPAVERINE HYDROCHLORIDE, DIGITALIS DERIVATIVES, AMINOPHYLLIN, CAFFEIN, GLUCOSE, CALCIUM GLUCONATE AND METRAZOL JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 306 OP 310 VO 72 IS 3 A1 E. LINDNER A1 L. N. KATZ YR 1941 UL http://jpet.aspetjournals.org/content/72/3/306.abstract AB 1. The digitalis derivatives, K-strophanthin, ouabain and digifoline at times have a direct coronary constrictor action even in therapeutic doses. 2. Metrazol and glucose are mild direct coronary dilators. 3. Calcium gluconate, in contrast with the chloride salt which is a powerful dilator of the coronary vessels, does not cause any constant or striking change in coronary caliber except that a mild dilatation occurs with large doses. 4. Aminophyllin and caffein sodium benzoate are consistently direct coronary dilators, the aminophyllin being the more powerful. 5. Papaverine hydrochloride is a powerful long-lasting direct coronary dilating agent. This and its tendency to prevent ventricular fibrillation probably explain its clinical benefits.