RT Journal Article
SR Electronic
T1 EXCRETION OF COMBINED MORPHINE IN THE TOLERANT AND NON-TOLERANT DOG
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 138
OP 145
VO 72
IS 2
A1 VINCENT THOMPSON
A1 E. G. GROSS
YR 1941
UL http://jpet.aspetjournals.org/content/72/2/138.abstract
AB 1. The "combined morphine" in urine of morphinized dogs may be separated into "easily" and "difficultly hydrolyzable" fractions. 2. Tolerant dogs excrete relatively greater amounts of the "easily hydrolyzable" fraction of the combined morphine than do non-tolerant dogs. 3. Seven to twenty-four hours after injection of morphine, urine of tolerant dogs contains mostly free morphine. During this same period, non-tolerant dogs excrete relatively large amounts of the "difficultly hydrolyzable" morphine fraction. 4. Tolerant dogs reach a peak in rate of morphine excretion more quickly than do the non-tolerant animals. The latter, however, continue to excrete relatively large quantities of morphine after the drug has practically disappeared from the urine of tolerant dogs.