PT  - JOURNAL ARTICLE
AU  - RAFAEL MENDEZ
AU  - ABE RAVIN
TI  - ON THE ACTION OF PROSTIGMINE ON THE CIRCULATORY SYSTEM
DP  - 1941 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 80--89
VI  - 72
IP  - 1
4099  - http://jpet.aspetjournals.org/content/72/1/80.short
4100  - http://jpet.aspetjournals.org/content/72/1/80.full
SO  - J Pharmacol Exp Ther1941 May 01; 72
AB  - The actions of prostigmine on the circulatory system have been studied on the heart-lung preparation of the dog, on the isolated frog heart, and on the cat. Of these actions, the following are referable to the inhibition of cholinesterase: the actions on the heart rate, stroke volume, total output, and coronary flow of the heart-lung preparation of the dog; the increased response to vagal stimulation, the slowing of the heart rate, the drop in blood pressure, and the more pronounced effect upon the blood pressure following injection of acetylcholine in the cat. The action of prostigmine on the isolated frog heart and the increase in blood pressure in the cat usually produced by the first injection of prostigmine and always produced after atropine are not explained by the inhibition of cholinesterase.