PT  - JOURNAL ARTICLE
AU  - EDWIN J. DEBEER
AU  - PAUL E. TULLAR
TI  - THE BIOLOGICAL ESTIMATION OF ERGOMETRINE
DP  - 1941 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 256--260
VI  - 71
IP  - 3
4099  - http://jpet.aspetjournals.org/content/71/3/256.short
4100  - http://jpet.aspetjournals.org/content/71/3/256.full
SO  - J Pharmacol Exp Ther1941 Mar 01; 71
AB  - It was found that both the mydriatic and the hyperthermal effects produced by ergometrine in the rabbit are quantitatively related to the dose and thus either may serve as a basis for the quantitative estimation of this drug. When both of these effects are considered simultaneously qualitative properties are acquired in addition. It is then possible to distinguish between the results produced by ergometrine and those of ergotoxine. Effective doses of ergometrine were found to be less toxic than those of ergotoxine. Using 16 rabbits for an assay, limits of error of about ± 20 per cent may be expected.