PT  - JOURNAL ARTICLE
AU  - HANS SELYE
TI  - ON THE RÔLE OF THE LIVER IN THE DETOXIFICATION OF STEROID HORMONES AND ARTIFICIAL ESTROGENS
DP  - 1941 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 236--238
VI  - 71
IP  - 3
4099  - http://jpet.aspetjournals.org/content/71/3/236.short
4100  - http://jpet.aspetjournals.org/content/71/3/236.full
SO  - J Pharmacol Exp Ther1941 Mar 01; 71
AB  - Experiments in the rat show that the anesthetic action as well as the toxic effect of acute overdosage by the intraperitoneal administration of desoxycorticosterone acetate, progesterone, testosterone benzoate, α-estradiol and stilbestrol is greatly increased in animals in which the major part of the liver has been removed. Since this operation does not increase sensitivity to other anesthetics such as ether and magnesium chloride, but is known to sensitize animals to the action of anesthetics which are detoxified in the liver (e.g. tribromethanol), it appears most probable that the liver is the site at which all the above mentioned compounds are normally detoxified.