TY - JOUR T1 - TOXICITY OF NAPHTHOQUINONES WITH VITAMIN K ACTIVITY IN MICE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 210 LP - 214 VL - 71 IS - 3 AU - MICHAEL B. SHIMKIN Y1 - 1941/03/01 UR - http://jpet.aspetjournals.org/content/71/3/210.abstract N2 - The acute and chronic toxicity of six naphthoquinones with vitamin K activity were studied in mice. The compounds at high doses are respiratory depressants and produce acute vascular congestion which is sufficient to cause hemorrhagic extravasation in the renal tubules and in the liver. No weight loss, anemia, or morphologic changes were observed in mice which were injected subcutaneously with 4 to 18 mgm. of 2-methyl-1, 4-naphthoquinone during 3 to 6 weeks. ER -