TY - JOUR T1 - CHEMOTHERAPEUTIC ACTIVITY OF N<sup>4</sup>-ACYLSULFANILHYDROXAMIDES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 52 LP - 58 VL - 71 IS - 1 AU - BETTYLEE HAMPIL AU - G. W. WEBSTER AU - MAURICE L. MOORE Y1 - 1941/01/01 UR - http://jpet.aspetjournals.org/content/71/1/52.abstract N2 - Fourteen members of a series of N4-acylsulfanilhydroxamides and four related compounds have been tested for chemotherapeutic activity. Three of the derivatives, n-valeryl, n-hexanoyl and n-heptanoyl, possess a high degree of efficacy in combating experimental streptococcal infections in mice. They have also been found to be effective against a strain of meningococcus. Blood concentrations of N4-hexanoylsulfanilhydroxamide, sulfanilamide and sulfapyridine have been determined in mice and correlated with chemotherapeutic activity. ER -