RT Journal Article
SR Electronic
T1 THE SMOOTH MUSCLE ACTIONS OF EPINEPHRINE SUBSTITUTES VII. RESPONSES OF DENERVATED SMOOTH MUSCLES OF IRIS AND INTESTINE TO EPINEPHRINE, EPHEDRINE, AMPHETAMINE (BENZEDRINE) AND COCAINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 251
OP 259
VO 66
IS 3
A1 MILES E. DRAKE
A1 R. JOHN F. RENSHAW
A1 FRED S. MODERN
A1 C. H. THIENES
YR 1939
UL http://jpet.aspetjournals.org/content/66/3/251.abstract
AB 1. The iris of cats and rabbits was denervated by excision of superior cervical ganglion. Two weeks was allowed for nerve degeneration. 2. Mydriasis in the normal eye was caused by instillation of epinephrine, ephedrine, amphetamine (benzedrine) or cocaine. 3. Denervation of the cat's iris prevented mydriasis by ephedrine or cocaine. Amphetamine mydriasis persisted and epinephrine nephrine mydriasis was increased (sensitization). 4. Denervation of the rabbit iris prevented mydriasis by amphetamine or cocaine. Ephedrine mydriasis persisted and there was sensitization to epinephrine. 5. Sympathetic postganglionic denervation of the small intestine of cats, rabbits and monkeys was accomplished by section of one or more branches of the superior mesenteric artery, with accompanying nerves. Two weeks was allowed for nerve degeneration. 6. Such denervated loops of intestine exhibited a sensitization toward epinephrine but no alteration in response to ephedrine, emphetamine or cocaine.