RT Journal Article
SR Electronic
T1 THE INHIBITION OF CHOLINE ESTERASE BY THIAMINE (VITAMIN B<sub>1</sub>)
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 389
OP 394
VO 65
IS 4
A1 DAVID GLICK
A1 WILLIAM ANTOPOL
YR 1939
UL http://jpet.aspetjournals.org/content/65/4/389.abstract
AB The inhibition by thiamine of the choline esterase in horse and rat serum has been studied, and it was observed that inhibitions were obtained only with concentrations of thiamine in excess of those known at present to occur within living organisms. The affinity of thiamine for choline esterase was calculated to be 26 times that of acetyl choline for the enzyme.