PT  - JOURNAL ARTICLE
AU  - G. B. WALLACE
AU  - B. B. BRODIE
AU  - M. FRIEDMAN
AU  - DAVID BRAND
TI  - THE DISTRIBUTION OF ADMINISTERED BROMIDE IN COMPARISON WITH CHLORIDE AND ITS RELATION TO BODY FLUIDS
DP  - 1939 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 214--219
VI  - 65
IP  - 2
4099  - http://jpet.aspetjournals.org/content/65/2/214.short
4100  - http://jpet.aspetjournals.org/content/65/2/214.full
SO  - J Pharmacol Exp Ther1939 Feb 01; 65
AB  - 1. The distribution of administered bromide in various tissues of body was determined and compared to that of chloride normally present. 2. It was found that wet tissue/serum ratios of bromide and chloride were in close agreement for all tissues except the brain, showing that these anions distribute in a similar manner in these tissues. 3. With the general acceptance of the evidence that chloride is distributed mainly, if not entirely, in extracellular fluid in inorganic form, it is concluded from our experiments that bromide is distributed in organs in like manner. 4. The similarity of distribution of chloride and bromide makes a selective chemical or physical relationship of the latter to tissue cells improbable.