PT  - JOURNAL ARTICLE
AU  - WILLIAM H. CROSBY
TI  - THE VASOCONSTRICTOR ACTION OF COCAINE
DP  - 1939 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 150--155
VI  - 65
IP  - 2
4099  - http://jpet.aspetjournals.org/content/65/2/150.short
4100  - http://jpet.aspetjournals.org/content/65/2/150.full
SO  - J Pharmacol Exp Ther1939 Feb 01; 65
AB  - The ability of cocaine to constrict the conjunctival and aural vessels of rabbits is not due to a potentiation of the vasoconstrictor action of adrenalin. Experiments involving interruption of the sympathetic pathways at various points and experiments with ergotoxine suggest that the site of action of cocaine is a dual one involving 1) a sensitization of the smooth muscle of the blood vessel wall to tonic sympathetic discharges and 2) an adrenalin-like action upon the sympathetic receptors of the muscle cell.