RT Journal Article
SR Electronic
T1 A STUDY OF CHOLINE ESTERASE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 264
OP 276
VO 59
IS 3
A1 M. H. ROEPKE
YR 1937
UL http://jpet.aspetjournals.org/content/59/3/264.abstract
AB 1. The dissociation constants of the enzyme-substrate-complex for choline esterase have been determined for acetylcholine, acetylarsenocholine and butyrlcholine as substrates. 2. Choline, arsenocholine, acetyl-β-methylcholine, tetramethylammonium chloride, tropine, l-hyocyamine, d-hyocyamine, atropine, NaCl, KCl and NH4Cl are competitive inhibitors of choline esterase. The dissociation constants of the enzyme-inhibitor-complex have been determined for these compounds. 3. The inhibition of the esterase by carbamylcholine, physostigmine and prostigmine is discussed. 4. The question of the use of choline esterase as a model for the cell receptors is discussed in connection with theories on the mode of action of the choline-like compounds.