RT Journal Article SR Electronic T1 THE INFLUENCE OF DRUGS ON THE HUMAN SENSORY THRESHOLD JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 527 OP 532 VO 6 IS 4 A1 E. G. MARTIN A1 C. M. GRACE A1 J. H. McGUIRE YR 1915 UL http://jpet.aspetjournals.org/content/6/4/527.abstract AB Two subjects showed marked lowering of general sensitiveness within one hour after the administration of acetphenetedin (5-15 grains) by mouth. The criterion was the threshold for electrocutaneous sensibility (Martin method). One of the subjects, the one with greater normal sensitiveness, gave evidence of a certain degree of tolerance after ten doses, distributed over a period of two months. The other subject reacted markedly throughout the investigation, and was generally more affected by the larger doses than by the smaller ones.