RT Journal Article
SR Electronic
T1 STUDIES OF CHRONIC MORPHINE POISONING IN DOGS VI. EFFECT OF INCREASING TISSUE OXIDATIONS BY DINITROPHENOL ON THE EXCRETION OF MORPHINE IN TOLERANT AND NON-TOLERANT DOGS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 417
OP 427
VO 58
IS 4
A1 O. H. PLANT
A1 D. SLAUGHTER
YR 1936
UL http://jpet.aspetjournals.org/content/58/4/417.abstract
AB 1. The increase in cellular metabolism that follows the administration of small doses of dinitrophenol markedly decreases the excretion of morphine in non-tolerant dogs, but does not materially modify the excretion of the alkaloid in tolerant animals. 2. These findings confirm the results obtained in recovery of morphine from the tissues and indicate that the mechanism by which morphine is handled by the tissues of tolerant dogs differs from that in non-tolerant animals.