PT  - JOURNAL ARTICLE
AU  - O. H. PLANT
AU  - D. SLAUGHTER
TI  - STUDIES OF CHRONIC MORPHINE POISONING IN DOGS VI. EFFECT OF INCREASING TISSUE OXIDATIONS BY DINITROPHENOL ON THE EXCRETION OF MORPHINE IN TOLERANT AND NON-TOLERANT DOGS
DP  - 1936 Dec 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 417--427
VI  - 58
IP  - 4
4099  - http://jpet.aspetjournals.org/content/58/4/417.short
4100  - http://jpet.aspetjournals.org/content/58/4/417.full
SO  - J Pharmacol Exp Ther1936 Dec 01; 58
AB  - 1. The increase in cellular metabolism that follows the administration of small doses of dinitrophenol markedly decreases the excretion of morphine in non-tolerant dogs, but does not materially modify the excretion of the alkaloid in tolerant animals. 2. These findings confirm the results obtained in recovery of morphine from the tissues and indicate that the mechanism by which morphine is handled by the tissues of tolerant dogs differs from that in non-tolerant animals.