RT Journal Article
SR Electronic
T1 THE PHARMACOLOGICAL ACTION OF THE ALKALOIDS OF FUMARACEOUS PLANTS III. DICENTRINE METHINE HYDROCHLORIDE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 332
OP 336
VO 58
IS 3
A1 R. A. WAUD
YR 1936
UL http://jpet.aspetjournals.org/content/58/3/332.abstract
AB The action of dicentrine on intact animals, blood pressure, perfused heart, uterine strips, decerebrate and decapitate animals has been studied. It was found that the action of this drug is similar to that of corydine. Small doses in frogs produce drowsiness and depression, while larger doses result in convulsions which cease on pithing the cord. In the perfused frog's heart dicentrine produces diminution in the amplitude and heart block. Uterine muscle is depressed. Blood pressure in rabbits is reduced and removal of the cerebral hemispheres has little or no effect on the convulsions in rabbits, while technical difficulties prevented conclusive results in decapitate animals.