RT Journal Article
SR Electronic
T1 COLLOIDAL URANIUM
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 58
OP 64
VO 63
IS 1
A1 A. H. MALONEY
A1 A. F. BURTON
YR 1938
UL http://jpet.aspetjournals.org/content/63/1/58.abstract
AB The gross toxic effects of colloidal uranium are studied in the light of the known actions of uranium nitrate: 1. In doses of 1 mgm. per kilogram administered at intervals of ten minutes five or six times, colloidal uranium exerts no significant effect on the blood pressure or respiration. 2. Administered in daily doses of 1 mgm. per kilogram to kittens it produces a gradual weight loss leading to death within three weeks to one month. 3. As a rule animals can tolerate a single dose of 1 to 5 mgm. per kilogram. This was found to be the case with mice, guinea pigs, kittens and cats. 4. Colloidal uranium is distinctly less toxic than uranium nitrate to the organism as a whole.