RT Journal Article
SR Electronic
T1 A BASIS FOR THE ACETYLCHOLINE ACTION OF CHOLINE DERIVATIVES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 430
OP 448
VO 62
IS 3
A1 R. R. RENSHAW
A1 D. GREEN
A1 M. ZIFF
YR 1938
UL http://jpet.aspetjournals.org/content/62/3/430.abstract
AB 1. The duration of activity of a series of choline derivatives when injected into the vein was measured and found to be approximately the same for all compounds studied. 2. The relative rates of inactivation of the same series of compounds by whole blood were measured and found to vary widely. 3. The duration of depressor activity of a blood-stable compound, ethoxycholine bromide, was prolonged by prior administrations of eserine, and to the same extent as that of acetylcholine. 4. The presence of a compound with the characteristics of acetylcholine was demonstrated in blood withdrawn from the heart of an animal undergoing infusion of ethoxycholine bromide. 5. It is suggested that the vasodepressant action of choline analogues is due, in part at least, to the liberation of acetylcholine by a process of cationic exchange adsorption. 6. A possible mechanism for the disposal of choline analogues, when injected into the blood stream, is discussed.