TY - JOUR T1 - THE FATE OF DRUGS USED IN SPINAL ANAESTHESIA JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 39 LP - 53 VL - 62 IS - 1 AU - KENNETH BULLOCK AU - A. D. MACDONALD Y1 - 1938/01/01 UR - http://jpet.aspetjournals.org/content/62/1/39.abstract N2 - 1. The literature dealing with the estimation of the concentration of local anaesthetics in body tissues, and the fate of such drugs when administered by intrathecal injection is reviewed. 2. A suitable technique for the estimation of local anaesthetics derived from para-amino-benzoic acid in cerebro-spinal fluid, blood and urine is described. 3. In spinal anaesthesia in the cat the concentration of drug rapidly falls at the point of injection. Little is present at any time in the blood, and little is excreted in the urine. The spread upwards from the point of injection is very limited. 4. Figures are given relating the average duration of anaesthesia with the concentration of drug injected. ER -