TY - JOUR T1 - THE EFFECT OF STAPHYLOCOCCUS AUREUS EXOTOXIN ON THE RABBIT HEART JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 121 LP - 129 VL - 61 IS - 2 AU - J. H. DINGLE AU - H. E. HOFF AU - L. H. NAHUM AU - B. W. CAREY, JR. Y1 - 1937/10/01 UR - http://jpet.aspetjournals.org/content/61/2/121.abstract N2 - 1. The exotoxin of Staphylococcus aureus, titrated for its dermonecrotic and haemolytic activity, was injected intravenously into eight normal and three anesthetized rabbits in varying doses. 2. Frequent electrocardiograms were taken from lead II, and in the three anesthetized animals the arterial blood pressure was simultaneously recorded. 3. Death occurred in from 1½ to 20 minutes, depending on the dosage. No effect was noted with doses less than 0.062 cc. per kilogram. 4. Collapse and death were preceded by evidence of progressively severe myocardial damage accompanied by venous engorgement. 5. Various rhythmic changes were observed, which had no causal relationship to the fatal outcome. ER -