PT - JOURNAL ARTICLE AU - DAVID I. MACHT TI - THE ACTION OF DRUGS ON THE ISOLATED PULMONARY ARTERY DP - 1914 Sep 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 13--37 VI - 6 IP - 1 4099 - http://jpet.aspetjournals.org/content/6/1/13.short 4100 - http://jpet.aspetjournals.org/content/6/1/13.full SO - J Pharmacol Exp Ther1914 Sep 01; 6 AB - 1. The action of a large number of drugs was studied on strips and rings of surviving pulmonary arteries. 2. Epinephrin causes a powerful constriction of the pulmonary artery. 3. After ergotoxin and a number of other drugs, the action of epinephrin on the isolated artery is inhibited. 4. These observations speak strongly in favor of a vaso-motor supply of the pulmonary artery. 5. Of the digitalis bodies, all except digitonin produce constriction. The latter causes a dilatation of the pulmonary ring. 6. The nitrites were found to produce a constriction of the pulmonary artery. 7. It is suggested that this anomalous action of the nitrites is due to the pulmonary artery being richly supplied for the most part with vase-constrictor nerve terminals. 8. This action of the nitrites is corroborated by other experimental and clinical data, and points to a rational method of treating haemoptysis.