%0 Journal Article %A DAVID I. MACHT %T THE ACTION OF DRUGS ON THE ISOLATED PULMONARY ARTERY %D 1914 %J Journal of Pharmacology and Experimental Therapeutics %P 13-37 %V 6 %N 1 %X 1. The action of a large number of drugs was studied on strips and rings of surviving pulmonary arteries. 2. Epinephrin causes a powerful constriction of the pulmonary artery. 3. After ergotoxin and a number of other drugs, the action of epinephrin on the isolated artery is inhibited. 4. These observations speak strongly in favor of a vaso-motor supply of the pulmonary artery. 5. Of the digitalis bodies, all except digitonin produce constriction. The latter causes a dilatation of the pulmonary ring. 6. The nitrites were found to produce a constriction of the pulmonary artery. 7. It is suggested that this anomalous action of the nitrites is due to the pulmonary artery being richly supplied for the most part with vase-constrictor nerve terminals. 8. This action of the nitrites is corroborated by other experimental and clinical data, and points to a rational method of treating haemoptysis. %U https://jpet.aspetjournals.org/content/jpet/6/1/13.full.pdf