PT  - JOURNAL ARTICLE
AU  - A. SIGAL
AU  - C. G. KING
TI  - THE INFLUENCE OF VITAMIN C DEFICIENCY UPON THE RESISTANCE OF GUINEA PIGS TO DIPHTHERIA TOXIN GLUCOSE TOLERANCE
DP  - 1937 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 1--9
VI  - 61
IP  - 1
4099  - http://jpet.aspetjournals.org/content/61/1/1.short
4100  - http://jpet.aspetjournals.org/content/61/1/1.full
SO  - J Pharmacol Exp Ther1937 Sep 01; 61
AB  - The glucose tolerance test was used to study the effect of different levels of vitamin C intake on the carbohydrate disturbance in guinea pigs caused by diphtheria toxin. The degree and duration of dysfunction was influenced to a significant degree by the state of nutrition of the animals. Sublethal injections of toxin caused a greater disturbance in animals receiving only enough vitamin to prevent scurvy, compared to those receiving a more generous supply. It is evident from the data presented that the level of vitamin C intake for optimum in vivo detoxification of diphtheria toxin is considerably greater than that necessary to protect from scurvy or to show a favorable growth rate.