%0 Journal Article %A A. SIGAL %A C. G. KING %T THE INFLUENCE OF VITAMIN C DEFICIENCY UPON THE RESISTANCE OF GUINEA PIGS TO DIPHTHERIA TOXIN GLUCOSE TOLERANCE %D 1937 %J Journal of Pharmacology and Experimental Therapeutics %P 1-9 %V 61 %N 1 %X The glucose tolerance test was used to study the effect of different levels of vitamin C intake on the carbohydrate disturbance in guinea pigs caused by diphtheria toxin. The degree and duration of dysfunction was influenced to a significant degree by the state of nutrition of the animals. Sublethal injections of toxin caused a greater disturbance in animals receiving only enough vitamin to prevent scurvy, compared to those receiving a more generous supply. It is evident from the data presented that the level of vitamin C intake for optimum in vivo detoxification of diphtheria toxin is considerably greater than that necessary to protect from scurvy or to show a favorable growth rate. %U https://jpet.aspetjournals.org/content/jpet/61/1/1.full.pdf