TY - JOUR T1 - LOCAL ANAESTHETICS DERIVED FROM THE ALKALOID CYTISINE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 401 LP - 412 VL - 59 IS - 4 AU - H. RAYMOND ING AU - R. P. PATEL Y1 - 1937/04/01 UR - http://jpet.aspetjournals.org/content/59/4/401.abstract N2 - 1. Seven N-alkyl ester derivatives of cytisine have been tested for toxicity and local anaesthetic activity. 2. Four of them compared favourably with cocaine on the rabbit's cornea and two of them compared favourably with cocaine on intradermal injection in man. 3. One of them (CPB) was tested for the typical nicotine properties of cytisine, which proved to be absent. It is a pleasure to record our thanks to Professor J. H. Gaddum for much help and advice and to Dr. H. Rydin who made the intradermal injections. We also wish to make acknowledgments to the Alembic Chemical Works, Baroda, for a loan to one of us (R.P.P.). ER -